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  4. ADPGK Antibody

ADPGK Antibody

  • 中文名稱：
    ADPGK兔多克隆抗體
  • 貨號：
    CSB-PA001380ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: ADPGK antibody at 1.02µg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 55, 54, 29, 25, 39, 9 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA001380ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA001380ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ADPGK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ADPGK
  • 別名：
    2610017G09Rik antibody; ADP dependent glucokinase antibody; ADP GK antibody; ADP-dependent glucokinase antibody; ADP-GK antibody; ADPGK antibody; ADPGK_HUMAN antibody; ATP dependent glucokinase antibody; DKFZP434B195 antibody; RbBP 35 antibody; RbBP-35 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ADP-dependent glucokinase protein (218-497AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency.
  • 基因功能參考文獻：
    1. ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose PMID: 26555263
    2. ADPGK can contribute to tumour cell survival under conditions of high glycolytic dependence. PMID: 23799003
    3. human ADPGK(ADP-dependent glucokinase) catalyses ADP-dependent phosphorylation of glucose in vitro, but despite its high expression in human tumour cell lines it appears not to make a quantifiable contribution to glycolysis under the conditions evaluated. PMID: 22219026
    4. Glucose and insulin response to oral glucose is higher in GCK(261) carriers, indicating clinical heterogeneity in GCK maturity diabetes carriers. PMID: 19903754
    5. The presence of mild persistent hyperglycemia in any patient without autoantibodies should lead to genetic analysis of glucokinase, particularly if there is a positive family history. PMID: 19309449

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    ADP-dependent glucokinase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25250

    OMIM: 611861

    KEGG: hsa:83440

    STRING: 9606.ENSP00000312250

    UniGene: Hs.562587