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  4. AFF2 Antibody

AFF2 Antibody

  • 中文名稱：
    AFF2兔多克隆抗體
  • 貨號：
    CSB-PA114461
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA114461(AFF2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA114461(AFF2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal lung tissue, Primary antibody: CSB-PA114461(AFF2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    AFF2
  • 別名：
    AF4/FMR2 family member 2 antibody; AF4/FMR2 family, member 2 antibody; AFF2 antibody; AFF2_HUMAN antibody; FMR2 antibody; FMR2P antibody; Fragile X E mental retardation syndrome protein antibody; fragile X mental retardation 2 antibody; Fragile X mental retardation 2 protein antibody; fragile X mental retardation gene associated with FRAXE antibody; FRAXE antibody; mild or borderline mental retardation antibody; MRX2 antibody; OTTHUMP00000024204 antibody; OX19 antibody; Protein FMR-2 antibody; Protein Ox19 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human AFF2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    150mM?NaCl,?0.02%?sodium?azide?and?50%?glycerol.pH?7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.
  • 基因功能參考文獻：
    1. Partial AFF2 microduplication in a patient with auditory processing disorder, emotional impairment and macrosomia. PMID: 25256661
    2. FMR2 is an upstream regulator of FOS and JUN, and further link deregulation of the immediate early response genes to the pathology of ID- and FRAXE-associated ID in particular. PMID: 23562910
    3. 2.5% of males Autism spectrum disorder patients had missense mutations in AFF2 at highly conserved evolutionary sites. PMID: 22773736
    4. A report of novel deletions involving AFF2 provide evidence for a new mutational spectrum, microdeletions, that are responsible for Fragile X E in a small subset of patients. PMID: 22065534
    5. overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles. PMID: 21330300

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  • 相關(guān)疾?。?/div>
    Mental retardation, X-linked, associated with fragile site FRAXE (MRFRAXE)
  • 亞細胞定位：
    Nucleus speckle. Note=When splicing is inhibited, accumulates in enlarged speckles.
  • 蛋白家族：
    AF4 family
  • 組織特異性：
    Brain (most abundant in hippocampus and amygdala), placenta and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3776

    OMIM: 300806

    KEGG: hsa:2334

    STRING: 9606.ENSP00000359489

    UniGene: Hs.496911