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ALDH3B1 Antibody

  • 中文名稱：
    ALDH3B1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA272345
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA272345(ALDH3B1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA272345(ALDH3B1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human normal kidney tissue, Human liver tissue, human liver cancer tissue, Primary antibody: CSB-PA272345(ALDH3B1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 45 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ALDH3B1
  • 別名：
    ALDH3B1 antibody; ALDH7Aldehyde dehydrogenase family 3 member B1 antibody; EC 1.2.1.28 antibody; EC 1.2.1.5 antibody; EC 1.2.1.7 antibody; Aldehyde dehydrogenase 7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ALDH3B1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor. May have a protective role against the cytotoxicity induced by lipid peroxidation.
  • 基因功能參考文獻(xiàn)：
    1. the likely physiological function of ALDH3B1 is to oxidize lipid-derived aldehydes generated in the plasma membrane and not to be involved in the sphingolipid metabolism in the endoplasmic reticulum. PMID: 23721920
    2. protects cells from the damaging effects of oxidative stress PMID: 20699116
    3. The specificity of ALDH3B1 distribution may prove to be directly related to the functional role of this enzyme in human tissues. PMID: 20729348
    4. This study shows for the first time the functionality, expression and protective role of ALDH3B1 and indicates a potential physiological role of ALDH3B1 against oxidative stress. PMID: 17382292
    5. These findings provided convincing evidence that epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes plays an important role in the pathogenesis of schizophrenia PMID: 19159868
    6. Initial characterization of human ALDH3B1 suggests a potential physiological role of this protein in oxidative stress processes. PMID: 17382292

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.
  • 蛋白家族：
    Aldehyde dehydrogenase family
  • 組織特異性：
    Highest expression in kidney and lung.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 410

    OMIM: 600466

    KEGG: hsa:221

    UniGene: Hs.523841