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  4. CBR4 Antibody

CBR4 Antibody

  • 中文名稱：
    CBR4兔多克隆抗體
  • 貨號：
    CSB-PA850803ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA850803ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA850803ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CBR4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CBR4
  • 別名：
    3 oxoacyl [acyl carrier protein] reductase antibody; 3-oxoacyl-[acyl-carrier-protein] reductase antibody; Carbonic reductase 4 antibody; Carbonyl reductase 4 antibody; Carbonyl reductase family member 4 antibody; CBR 4 antibody; Cbr4 antibody; CBR4_HUMAN antibody; FLJ14431 antibody; Quinone reductase CBR4 antibody; SDR45C1 antibody; Short chain dehydrogenase/reductase family 45C member 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Carbonyl reductase family member 4 protein (1-237AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
  • 基因功能參考文獻(xiàn)：
    1. CBR4 is a mitochondrial NADPH-dependent reductase for o- and p-quinones. PMID: 19000905
    2. Hs17beta-HSD8 and HsCBR4 show a strong genetic interaction in vivo in yeast, where, only if they are expressed together, they rescue the respiratory deficiency and restore the lipoic acid content of oar1Delta cells. PMID: 19571038
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性：
    Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25891

    KEGG: hsa:84869

    STRING: 9606.ENSP00000303525

    UniGene: Hs.659311