CDC42EP2 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

O14613
基因名：

CDC42EP2
別名：

Binder of Rho GTPases 1 antibody; BORG1 antibody; BORG1_HUMAN antibody; CDC42 effector protein (Rho GTPase binding) 2 antibody; Cdc42 effector protein 2 antibody; Cdc42ep2 antibody; CEP2 antibody; CRIB-containing BOGR1 protein antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Human CDC42EP2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner.
基因功能參考文獻：
1. Studies indicate some of the functional and mechanistic roles of the binder of Rho GTPases Borg1-5 proteins (Cdc42EP1-5), including cytoskeletal remodelling and signalling. PMID: 27913681
2. CDC42EP2 is upregulated in human PDLCs subjected to tensile stress related to mechano-induced cell cycle arrest. PMID: 20934684
3. activations of Rac1 and Cdc42 are involved in the hypoxia-induced production of angiogenesis-promoting factors and tumor suppressors, and suggest that the Rho family GTPases Rac1 and Cdc42 may contribute to the hypoxia-mediated angiogenesis. PMID: 16395716
亞細胞定位：

Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton.
蛋白家族：

BORG/CEP family
組織特異性：

Highly expressed in the heart. Weakly expressed in the pancreas and liver.
數(shù)據(jù)庫鏈接：

HGNC: 16263

OMIM: 606132

KEGG: hsa:10435

STRING: 9606.ENSP00000279249

UniGene: Hs.343380