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CEP72 Antibody

  • 中文名稱：
    CEP72兔多克隆抗體
  • 貨號(hào)：
    CSB-PA889176DSR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA889176DSR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA889176DSR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CEP72 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CEP72
  • 別名：
    Centrosomal protein 72kDa antibody; Centrosomal protein of 72 kDa antibody; Cep72 antibody; CEP72_HUMAN antibody; FLJ10565 antibody; MGC5307 antibody; RGD1566336 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Centrosomal protein of 72 kDa protein (200-460AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2.
  • 基因功能參考文獻(xiàn)：
    1. CEP72-ROS1 is a novel ROS1 fusion variant in non-small cell lung cancer (NSCLC) discovered by next-generation sequencing and could be included in ROS1 detection assay, such as reverse transcription PCR. PMID: 29517860
    2. CEP72 represents a putative oncogene in colorectal cancer that might negatively regulate the mitotic function of BRCA1 to ensure chromosomal stability PMID: 26300001
    3. The CEP72 polymorphism can identify adults at increased risk of vincristine-induced peripheral neuropathy PMID: 27618250
    4. aim of this study was to determine whether the CEP72 rs924607 TT genotype is a useful marker of vincristine neuropathy during induction therapy among Spanish children with B-ALL treated on the LAL-SHOP protocols PMID: 26618658
    5. In this study an inherited polymorphism in the promoter region of CEP72 was associated with increased risk and severity of vincristine-related peripheral neuropathy. PMID: 25710658
    6. Findings show that Cep72 is the key protein essential for maintaining microtubule-organizing activity and structural integrity of the centrosome. PMID: 19536135

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  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.
  • 蛋白家族：
    CEP72 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25547

    OMIM: 616475

    KEGG: hsa:55722

    STRING: 9606.ENSP00000264935

    UniGene: Hs.591741