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DLST Antibody, Biotin conjugated

  • 中文名稱：
    DLST兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA861526LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DLST Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DLST
  • 別名：
    2-oxoglutarate dehydrogenase complex component E2 antibody; Dihydrolipoamide S succinyltransferase (E2 component of 2 oxo glutarate complex) antibody; Dihydrolipoamide S succinyltransferase antibody; Dihydrolipoamide succinyltransferase component of 2 oxoglutarate dehydrogenase complex antibody; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex antibody; Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex antibody; Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex mitochondrial antibody; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex antibody; Dlst antibody; DLTS antibody; E2 antibody; E2K antibody; mitochondrial antibody; ODO2_HUMAN antibody; OGDC-E2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial protein (76-225AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
  • 基因功能參考文獻：
    1. RNAi knockdown of DLST led to decreased cell viability and induction of apoptosis in human T-ALL cell lines PMID: 26876595
    2. 2-oxoglutarate dehydrogenase complex (OGDHC), the key regulatory enzyme of Krebs cycle. [review] PMID: 22235656
    3. Data show that the dihydrolipoamide succinyltransferase gene is bifunctional, and truncated mRNA transcribed from it contributes to the biogenesis of the mitochondrial respiratory complexes. PMID: 12805207
    4. Association between late-onset Alzheimer disease shows strong linkage disequilibrium across the DLST locus. PMID: 15038610
  • 亞細胞定位：
    Mitochondrion matrix. Nucleus.
  • 蛋白家族：
    2-oxoacid dehydrogenase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2911

    OMIM: 126063

    KEGG: hsa:1743

    STRING: 9606.ENSP00000335304

    UniGene: Hs.525459