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GNA15 Antibody

  • 中文名稱：
    GNA15兔多克隆抗體
  • 貨號：
    CSB-PA009587ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: GNA15 antibody at 1.41 μg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 44 kDa
      Observed band size: 44, 24, 72 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA009587ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA009587ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GNA15 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    G alpha 15 antibody; G alpha 16 antibody; G alpha-15 antibody; G alpha-16 antibody; G-protein subunit alpha-15 antibody; G-protein subunit alpha-16 antibody; GNA 15 antibody; GNA 16 antibody; GNA15 antibody; GNA15_HUMAN antibody; GNA16 antibody; Gq class antibody; Guanine nucleotide binding protein alpha 15 antibody; Guanine nucleotide binding protein alpha 15 subunit antibody; Guanine nucleotide-binding protein subunit alpha-15 antibody; Guanine nucleotide-binding protein subunit alpha-16 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Guanine nucleotide-binding protein subunit alpha-15 protein (1-374AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
  • 基因功能參考文獻：
    1. GNA15 was not expressed in normal neuroendocrine cells but was overexpressed in gastroenteropancreatic neuroendocrine neoplasia cell lines. PMID: 25701539
    2. Data indicate the importance of Galpha16 as a downstream effector of the non-canonical Wnt signaling pathway and as a potential therapeutic target for the treatment of non small cell lung cancer. PMID: 24204697
    3. G15 ectopic presence could functionally contribute to the transformation process since siRNA-induced depletion of Galpha15 in pancreatic carcinoma cell lines dramatically inhibited anchorage-independent growth and resistance to the lack of nutrients. PMID: 23200847
    4. The paper describes G alpha 15 resistance to arrestin-desensitization making it differ from other heterotrimeric G proteins (Gq, Gs, Gi, G12/13 class) PMID: 19275934
    5. This paper shows how G alpha 15 and other Gq class members phosphorylate PKD in differing patterns PMID: 22227248
    6. This review summarizes the specific features that distinguish Galpha15/GNA15 (G15 alpha subunit) from all other alpha subunits of the Gq class. G15 is a heterotrimeric G protein complex that is named after its alpha subunit. PMID: 20150327
    7. beta3 region of Galpha16 is essential for interaction with TPR1 and the subsequent activation of Ras PMID: 21486497
    8. Megakaryocytopoiesis was accompanied by down-regulation of the 43 kDa and 46 kDa variants of G16alpha, constant expression of Gsalpha, and up-regulation of Gqalpha and Gialpha1/2. PMID: 11686331
    9. role of intracellular loops of cannabinoid CB1 receptor in functional interaction with Galpha16. PMID: 12095632
    10. G protein-coupled receptors activate STAT3 via G alpha(16), a G alpha subunit which is primarily expressed in hematopoietic cells. PMID: 12670499
    11. Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism PMID: 14551213
    12. Results suggest that the G(q) class proteins are degraded through the proteasome pathway and that cellular localization and/or other protein interactions determine their stability. PMID: 16218966
    13. Co-stimulation of G(s) and G(q) can result in the fine-tuning of STAT3 activation status, and this may provide the basis for cell type-specific responses following activation of hIP. PMID: 18755267
    14. The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses. PMID: 19687291

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  • 蛋白家族：
    G-alpha family, G(q) subfamily
  • 組織特異性：
    Specifically expressed in hematopoietic cells. Expressed in epididymis (at protein level).
  • 數據庫鏈接：

    HGNC: 4383

    OMIM: 139314

    KEGG: hsa:2769

    STRING: 9606.ENSP00000262958

    UniGene: Hs.73797