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GNPAT Antibody, FITC conjugated

  • 中文名稱(chēng)：
    GNPAT兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA009629LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) GNPAT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    GNPAT
  • 別名：
    Acyl CoA dihydroxyacetonephosphateacyltransferase antibody; Acyl-CoA:dihydroxyacetonephosphateacyltransferase antibody; DAP AT antibody; DAP-AT antibody; DAPAT antibody; DHAP AT antibody; DHAP-AT antibody; DHAPAT antibody; Dihydroxyacetone phosphate acyltransferase antibody; EC 2.3.1.42 antibody; Glycerone-phosphate O-acyltransferase antibody; Glyceronephosphate O acyltransferase antibody; GNPAT antibody; GNPAT_HUMAN antibody; OTTHUMP00000036147 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dihydroxyacetone phosphate acyltransferase protein (589-680AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Dihydroxyacetonephosphate acyltransferase involved in plasmalogen biosynthesis.
  • 基因功能參考文獻(xiàn)：
    1. GNPAT p.D519G is strongly associated with markedly increased iron stores in p.C282Y homozygotes after correction for age, iron-related variables, and alcohol consumption. PMID: 27936396
    2. GNPAT rs11558492 is not a major modifier of iron status and is not associated with liver fibrosis in HFE-related Hemochromatosis patients. PMID: 28425416
    3. Here, we report the characterization of the recombinant human DHAP acyl-transferase, which performs the first step in alkyl-DHAP synthesis. PMID: 27836547
    4. Reduction of GNPAT activated NF-kappaB in glial cell lines and microglia in cortex. PMID: 28292831
    5. C282Y homozygotes referred for HFE testing commonly have a GNPAT variant. This GNPAT variant does not appear be a co-modifying gene affecting expression of HFE related hemochromatosis in this population. The GNPAT variant does not predict the severity of iron overload. PMID: 27740525
    6. The variant of the GNPAT gene showed the most significant association with severe iron overload. PMID: 25605615
    7. ACOX1 and GNPAT silencing up-regulated ceramide galactosyltransferase (UGT8) mRNA expression, and down-regulated UDP-glucoseceramide glucosyltransferase (UGCG). PMID: 23933200
    8. Novel mutations in GNPAT cause rhizomelic chondrodysplasia punctata (RCDP) type 2. PMID: 21990100
    9. peroxisomal DHAPAT is essential for the biosynthesis of plasmalogens in animal cells PMID: 15687349
    10. Chromosome 1q42.1 harbors GNPAT and DISC1 as candidate genes for schizophrenia. PMID: 16997000

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  • 相關(guān)疾病：
    Rhizomelic chondrodysplasia punctata 2 (RCDP2)
  • 亞細(xì)胞定位：
    Peroxisome membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    GPAT/DAPAT family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4416

    OMIM: 222765

    KEGG: hsa:8443

    STRING: 9606.ENSP00000355607

    UniGene: Hs.498028