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GRM8 Antibody

  • 中文名稱：
    GRM8兔多克隆抗體
  • 貨號(hào)：
    CSB-PA009035
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    FLJ41058 antibody; GLUR8 antibody; Glutamate receptor metabotropic 8 antibody; GPRC1H antibody; GRM8 antibody; GRM8_HUMAN antibody; Metabotropic glutamate receptor 8 antibody; MGC126724 antibody; mGlu8 antibody; mGluR8 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human mGluR-8.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
  • 基因功能參考文獻(xiàn)：
    1. This study showed that GRM8 was nominally associated (p < 0.05) with both delta measures (energy and intertrial phase coherence). PMID: 27871913
    2. These results further implicate the role of glutamate receptor genes such as GRM8 in the development of alcohol dependence. PMID: 25978827
    3. Genome wide association study and meta-analysis results detected rs6951643, a GRM8 genetic variant as suggestive marker for sporadic Creutzfeldt-Jakob disease risk mapping outside the PRNP region. PMID: 25918841
    4. propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1, and GRM8). PMID: 24821406
    5. The GRM8 gene might play an important role in the pathogenesis of schizophrenia. PMID: 25588301
    6. Glutamate acts as a partial inverse agonist to metabotropic glutamate receptor with a single amino acid mutation in the transmembrane domain PMID: 23420844
    7. Eight suggestive significant loci were detected with a series of genes expressed within the inner ear that underlie the auditory function, such as: DCLK1, PTPRD, GRM8, CMIP. PMID: 21493956
    8. Pias1 binds to and sumoylates metabotropic glutamate receptor 8 PMID: 16144832
    9. GRM8 genes are likely involved in the pathogenesis of autistic disorder. PMID: 17955477
    10. Association of suingle nucleotide polymorphisms in GRM8 with theta power of event-related oscillations and alcohol dependence are reported. PMID: 18618593

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4600

    OMIM: 601116

    KEGG: hsa:2918

    STRING: 9606.ENSP00000344173

    UniGene: Hs.449625