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GZMK Antibody

  • 中文名稱(chēng)：
    GZMK兔多克隆抗體
  • 貨號(hào)：
    CSB-PA002797
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of Jurkat cells using Granzyme K Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Fragmentin 3 antibody; Fragmentin-3 antibody; Fragmentin3 antibody; GRAK_HUMAN antibody; Granzyme 3 antibody; granzyme K (granzyme 3; tryptase II) antibody; granzyme K (serine protease; granzyme 3; tryptase II) antibody; Granzyme K antibody; Granzyme K precursor antibody; Granzyme-3 antibody; Granzyme3 antibody; GranzymeK antibody; GZMK antibody; NK TRYP 2 antibody; NK TRYP2 antibody; NK tryptase 2 antibody; NK-TRYP-2 antibody; NK-tryptase-2 antibody; NKTRYP2 antibody; Serine protease granzyme 3 antibody; TRYP 2 antibody; TRYP2 antibody; Tryptase II antibody; TryptaseII antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Granzyme K.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. Extracellular granzyme K mediates endothelial activation through the cleavage of PAR-1. PMID: 26936634
    2. Extracellular GrK is an unexpected direct modulator of lipopolysaccharide-TLR4 signaling during the antimicrobial innate immune response. PMID: 24711407
    3. Granzyme K plays an important physiological role in immunoregulation of adaptive immunity underlying the cytotoxicity of CD56(bright) natural killer (NK) cells toward activated T cells. PMID: 21666061
    4. Gr3 proenzymes is activated by cathepsin C which concomitantly decreased the molecular weight to that of active Gr3. PMID: 20377743
    5. The 2.2-A crystal structure reveals a rigid zymogen with unusual features PMID: 12384499
    6. The present findings thus introduce the possibility that human beta-tryptase, after mast cell degranulation and exposure to neutral pH in the tissue, may dissociate into active monomers with properties that are distinct from the tetrameric counterpart. PMID: 12387726
    7. We found human GzmK triggers rapid cell death independently of caspase activation. The features of death are characterized by rapid externalization of phosphatidylserine, nuclear morphological changes and single-stranded DNA nicks. PMID: 17008916
    8. Rsults indicate that plasma levels of Granzyme K could serve as a useful diagnostic marker to stage sepsis, permitting better classification, specific treatments of patients, and may play a functional role in the development of sepsis. PMID: 17438453
    9. p53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy. PMID: 19201868

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  • 亞細(xì)胞定位：
    Secreted. Cytoplasmic granule.
  • 蛋白家族：
    Peptidase S1 family, Granzyme subfamily
  • 組織特異性：
    Expressed in lung, spleen, thymus and peripheral blood leukocytes.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4711

    OMIM: 600784

    KEGG: hsa:3003

    STRING: 9606.ENSP00000231009

    UniGene: Hs.277937