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  4. LARS2 Antibody

LARS2 Antibody

  • 中文名稱：
    LARS2兔多克隆抗體
  • 貨號：
    CSB-PA613580ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA613580ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) LARS2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    LARS2
  • 別名：
    HLASA antibody; KIAA0028 antibody; LARS 2 antibody; Lars2 antibody; Leucine translase antibody; Leucine tRNA ligase 2 antibody; Leucine tRNA ligase 2 mitocondrial antibody; Leucine tRNA ligase antibody; Leucine--tRNA ligase antibody; Leucyl tRNA synthetase 2 antibody; Leucyl tRNA synthetase 2 mitochondrial antibody; LeuRS antibody; MGC26121 antibody; mtLeuRS antibody; PRLTS4 antibody; Probable leucyl-tRNA synthetase, mitochondrial antibody; SYLM_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Probable leucine--tRNA ligase, mitochondrial protein (1-250AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. IARS2 knockdown inhibits proliferation, suppresses colony formation, and causes cell cycle arrest in AGS cells. PMID: 29071539
    2. ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2, CLPP and C10orf2 PMID: 26970254
    3. This represents the first independent replication of the involvement of LARS2 mutations in Perrault syndrome, contributing valuable information for the further understanding of this disease PMID: 26657938
    4. analysis of the CP1 domain in human mitochondrial leucyl-tRNA synthetase PMID: 26272616
    5. Leucyl tRNA synthetase is able to partially rescue defects caused by mutations in non-cognate itochondrial-tRNAs. PMID: 24413189
    6. Mutations in LARS2, encoding mitochondrial leucyl-tRNA synthetase, lead to premature ovarian failure and hearing loss in Perrault syndrome. PMID: 23541342
    7. No evidence to support previous data indicating a role in type 2 diabetes susceptibility in humans with LARS2 single nucleotide polymorphisms PMID: 19847392
    8. The alteration of aminoacylation tRNA(Leu(UUR)) caused by the A3243G mutation led to mitochondrial translational defects and thereby reduced the aminoacylated efficiencies of tRNA(Leu(UUR)) as well as tRNA(Ala) and tRNA(Met). PMID: 20194621
    9. Upregulation of LARS2 is a hallmark of 324A>G mutation. The accumulation of 3243A>G mutation in the brain may have a pathophysiologic role in bipolar disorder and schizophrenia. PMID: 15737668
    10. In this study, we provide evidence that the LARS2 gene may represent a novel type 2 diabetes susceptibility gene. PMID: 15919814
    11. There was investigated whether overexpression of human mitochondrial LeuRS suppressed translation and respiratory chain defects associated with the pathogenic A3243G mutation in human cells. PMID: 18796578
    12. data indicate that inactivation of LARS2 by both genetic and epigenetic mechanisms may be a common and important event in the carcinogenesis of nasopharyngeal carcinoma PMID: 19129950

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  • 相關(guān)疾病：
    Perrault syndrome 4 (PRLTS4); Hydrops, lactic acidosis, and sideroblastic anemia (HLASA)
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Class-I aminoacyl-tRNA synthetase family
  • 組織特異性：
    Ubiquitously expressed, but highest expression in tissues with high metabolic rates, such as skeletal muscle, heart, and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17095

    OMIM: 604544

    KEGG: hsa:23395

    STRING: 9606.ENSP00000265537

    UniGene: Hs.526975