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MAP1LC3C Antibody

  • 中文名稱：
    MAP1LC3C兔多克隆抗體
  • 貨號(hào)：
    CSB-PA915606
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA915606(MAP1LC3C Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA915606(MAP1LC3C Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    MAP1LC3C
  • 別名：
    ATG8J antibody; Autophagy-related protein LC3 C antibody; Autophagy-related ubiquitin-like modifier LC3 C antibody; LC3 like protein 2 antibody; MAP1 light chain 3 like protein 2 antibody; MAP1 light chain 3 like protein 3 antibody; MAP1 light chain 3-like protein 3 antibody; MAP1A/MAP1B LC3 C antibody; MAP1A/MAP1B light chain 3 C antibody; MAP1LC3C antibody; Microtubule-associated protein 1 light chain 3 gamma antibody; Microtubule-associated proteins 1A/1B light chain 3C antibody; MLP3C_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human MAP1LC3C
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins.
  • 基因功能參考文獻(xiàn)：
    1. a basal, housekeeping mitophagy pathway that involves piecemeal degradation of mitochondrial proteins in a LC3C- and p62-dependent manner and contributes to mitochondrial homeostasis maintenance when cells rely on oxidative phosphorylation. PMID: 29149599
    2. a non-canonical autophagy pathway reminiscent of LC3-associated phagocytosis contributes to Vpu counteraction of BST2 restriction. PMID: 27880899
    3. The WDR81 interacts with LC3C through canonical LC3-interacting regions in the BEACH domain, promoting LC3C recruitment to ubiquitinated proteins. PMID: 28404643
    4. Results indicate that TECPR2 Binds LC3and the complex is required for autophagosome formation, possibly through regulation of functional ER exit sites PMID: 26431026
    5. both autophagy-related 5 and microtubule-associated protein 1 light chain 3B levels are decreased in patients with melanomas as compared with those with benign nevi PMID: 24300435
    6. ccytoplasm against Salmonella. PMID: 23022382

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  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome. Note=LC3-II binds to the autophagic membranes.
  • 蛋白家族：
    ATG8 family
  • 組織特異性：
    Most abundant in placenta, lung and ovary.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13353

    OMIM: 609605

    KEGG: hsa:440738

    STRING: 9606.ENSP00000349785

    UniGene: Hs.534971