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  4. MYLK3 Antibody

MYLK3 Antibody

  • 中文名稱：
    MYLK3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA658362ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA658362ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA658362ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MYLK3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    caMLCK antibody; cardiac MLCK antibody; Cardiac MyBP C associated Ca/CaM kinase antibody; Cardiac-MyBP-C-associated Ca/CaM kinase antibody; MLC kinase antibody; MLCK antibody; MLCK2 antibody; Mylk3 antibody; MYLK3_HUMAN antibody; Myosin light chain kinase 3 antibody; Putative myosin light chain kinase 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Myosin light chain kinase 3 protein (1-240AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility.
  • 基因功能參考文獻(xiàn)：
    1. This study demonstrates that cyclic stretch disrupts tight junctions and adherens junctions by a JNK2, c-Src, and MLCK-dependent mechanism. PMID: 24722904
    2. Biochemical and physiological regulation of cardiac myocyte contraction by cardiac-specific myosin light chain kinase. PMID: 23863751
    3. These findings suggest that hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis via an MLCK and a PTEN-dependent pathway. PMID: 23591626
    4. Integrated cDNA expression analysis of failing human myocardia uncovered a novel protein kinase, cardiac-specific myosin light chain kinase (cardiac-MLCK), which acts on MLC2v. PMID: 17885681
    5. data indicate that the IL-1beta-induced increase in MLCK protein expression and Caco-2 TJ permeability was mediated by an increase in MLCK expression and activity and by an NF-kappaB-dependent increase in MLCK gene transcription PMID: 18390750

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 組織特異性：
    Restricted to heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29826

    OMIM: 612147

    KEGG: hsa:91807

    STRING: 9606.ENSP00000378288

    UniGene: Hs.130465