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  4. PCGF6 Antibody, Biotin conjugated

PCGF6 Antibody, Biotin conjugated

  • 中文名稱：
    PCGF6兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA871612LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PCGF6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    MBLR antibody; Mel18 and Bmi1 like RING finger protein antibody; Mel18 and Bmi1-like RING finger antibody; Pcgf6 antibody; PCGF6_HUMAN antibody; Polycomb group RING finger protein 6 antibody; RING finger protein 134 antibody; RNF134 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Polycomb group RING finger protein 6 protein (9-70AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
  • 基因功能參考文獻：
    1. Pcgf6 acts as a master regulator to maintain embryonic stem cell identity. PMID: 27247273
    2. regulation by cell cycle-dependent phosphorylation PMID: 12167161
    3. Thus, we did not find evidence for uniquely interacting partner proteins using this approach, but did identify four new lamin A/C interactive partners PMID: 16248985
    4. Study shows that JARID1d and MBLR occupy human Engrailed 2 gene and regulate its expression and histone H3 lysine 4 methylation levels. PMID: 17320162
    5. MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2. PMID: 18211895
    6. Mel-18 overexpression showed reduced glycogen synthase kinase-3beta phosphorylation, beta-catenin nuclear localization, T-cell factor/lymphoid enhancer factor promoter activity, and cyclin D1 mRNA level PMID: 18519679

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21156

    OMIM: 607816

    KEGG: hsa:84108

    STRING: 9606.ENSP00000358862

    UniGene: Hs.335808