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  4. RAB18 Antibody

RAB18 Antibody

  • 中文名稱：
    RAB18兔多克隆抗體
  • 貨號：
    CSB-PA098549
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HuvEc cells and MCF-7 cells, using RAB18 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RAB18 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human RAB18.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration.
  • 基因功能參考文獻：
    1. The authors found that the previously documented interaction between TRAPPII and COPI was also required for the recruitment of Rab18 to the lipid droplet. PMID: 28003315
    2. findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people. PMID: 24996981
    3. RAB18 is the direct target of miR-455-5p in gastric cancer. PMID: 27451075
    4. Warburg Micro syndrome is caused by RAB18 deficiency. PMID: 26063829
    5. These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets. PMID: 24997429
    6. High RAB18 expression is associated with glioma. PMID: 24477653
    7. Rab18-mediated membrane trafficking of FASN and NS3 facilitates dengue virus replication. PMID: 24696471
    8. Rab18 interacts with the HCV nonstructural protein NS5A. PMID: 23935497
    9. Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18. PMID: 23471881
    10. Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1, RAB3GAP2 and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2. [Review] PMID: 23176487
    11. performed autozygosity mapping in five consanguineous families with Warburg micro syndrome without RAB3GAP1/2 mutations and identified loss-of-function mutations in RAB18 PMID: 21473985
    12. Rab18 regulates lipid droplet-associated membrane formation PMID: 15914536
    13. analysis of a novel splice variant of human Rab18 gene PMID: 16147880
    14. Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion. PMID: 18349058
    15. Rab18 and Rab43 have key roles in ER-Golgi trafficking. PMID: 18664496
    16. Rab18 is recruited to lipid droplets during lipolysis PMID: 16207721

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  • 相關(guān)疾?。?/div>
    Warburg micro syndrome 3 (WARBM3)
  • 亞細胞定位：
    Apical cell membrane. Lipid droplet.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14244

    OMIM: 602207

    KEGG: hsa:22931

    STRING: 9606.ENSP00000349415

    UniGene: Hs.406799