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S100A3 Antibody

  • 中文名稱：
    S100A3兔多克隆抗體
  • 貨號：
    CSB-PA040284
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    S100A3
  • 別名：
    Protein S 100E antibody; Protein S-100E antibody; Protein S100 A3 antibody; Protein S100-A3 antibody; S100 calcium binding protein A3 antibody; S100 calcium-binding protein A3 antibody; S100a3 antibody; S100E antibody; S10A3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human S-100A3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.
  • 基因功能參考文獻：
    1. S100A3 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. One disulfide bridge is between Cys30 in the N-terminal pseudo-EF-hand and Cys68 in the C-terminal EF-hand (SS1), and another disulfide bridge attaches Cys99 in the C-terminal coil structure to Cys81 in helix IV (SS2). PMID: 21377473
    3. crystal structure of S100A3 at 1.7-A resolution PMID: 12045193
    4. structure was solved by MIRAS phasing PMID: 12136135
    5. Purification and characterization of the S100A3 protein from human hair cuticles. PMID: 12470658
    6. cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3) PMID: 18083705

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    S-100 family
  • 組織特異性：
    Skin specific, specifically expressed at the inner endocuticle of hair fibers.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10493

    OMIM: 176992

    KEGG: hsa:6274

    STRING: 9606.ENSP00000357701

    UniGene: Hs.557609