SCN7A Antibody

產(chǎn)品詳情

Uniprot No.：

Q01118
基因名：

SCN7A
別名：

SCN7A antibody; SCN6A antibody; Sodium channel protein type 7 subunit alpha antibody; Putative voltage-gated sodium channel subunit alpha Nax antibody; Sodium channel protein cardiac and skeletal muscle subunit alpha antibody; Sodium channel protein type VII subunit alpha antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Monkey
免疫原：

Synthesized peptide derived from the Internal region of Human Na+ CP type VIIα.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IF, ELISA

推薦稀釋比：

Protocols：

Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
基因功能參考文獻(xiàn)：
1. The authors demonstrated that the sodium channel Nax functions as a sodium sensor. With increased extracellular sodium, Nax up-regulates prostasin, which results in activation of the sodium channel ENaC. PMID: 26537257
2. SNP rs7565062 of SCN7A was significantly associated with essential hypertension in a Northern Han Chinese population PMID: 25393565
亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Sodium channel (TC 1.A.1.10) family, SCN7A subfamily
組織特異性：

Heart and uterus.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 10594

OMIM: 182392

KEGG: hsa:6332

STRING: 9606.ENSP00000386796

UniGene: Hs.596087