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SLC7A2 Antibody, FITC conjugated

  • 中文名稱：
    SLC7A2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA021714LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC7A2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC7A2
  • 別名：
    ATRC2 antibody; 20.5 antibody; Amino acid transporter; cationic 2 (low affinity) antibody; ATRC 2 antibody; CAT 2 antibody; CAT-2 antibody; CAT2 antibody; Cat2a antibody; Cat2b antibody; Cationic amino acid transporter 2A antibody; cationic amino acid transporter; y+ system; low affinity cationic amino acid transporter 2 antibody; CTR2_HUMAN antibody; HCAT 2 antibody; HCAT2 antibody; Low affinity cationic amino acid transporter 2 antibody; OTTHUMP00000216432 antibody; OTTHUMP00000216433 antibody; OTTMUSP00000041667 antibody; OTTMUSP00000041669 antibody; RCAT2 antibody; SLC7A 2 antibody; Slc7a2 antibody; Solute carrier family 7 member 2 antibody; T cell early activation protein antibody; Tea antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cationic amino acid transporter 2 protein (604-658AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). May play a role in classical or alternative activation of macrophages via its role in arginine transport.
  • 基因功能參考文獻(xiàn)：
    1. genetic association studies in population in Tennessee: Data suggest that an SNP in SLC7A2 (rs2720574) is associated with response to dietary calcium and magnesium in prevention of colorectal polyps and colorectal ademonas. PMID: 28501704
    2. Identification of cysteine residues in human cationic amino acid transporter hCAT-2A that are targets for inhibition by N-ethylmaleimide. PMID: 24019517
    3. A chimera carrying the functional domain of the orphan protein SLC7A14 in the backbone of SLC7A2 mediates trans-stimulated arginine transport. PMID: 22787143
    4. Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect. CAT2 and ODC were increased in mouse and human H pylori gastritis tissues. PMID: 20600019
    5. Insulin increased L-arginine transport and the mRNA levels for hCAT-1 and hCAT-2B PMID: 15064952

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
  • 組織特異性：
    Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11060

    OMIM: 601872

    KEGG: hsa:6542

    STRING: 9606.ENSP00000004531

    UniGene: Hs.448520