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  4. SMC1B Antibody, HRP conjugated

SMC1B Antibody, HRP conjugated

  • 中文名稱：
    SMC1B兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA854104LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SMC1B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    bK268H5 antibody; SMC protein 1B antibody; SMC-1-beta antibody; SMC-1B antibody; SMC1 beta antibody; SMC1B antibody; SMC1B_HUMAN antibody; SMC1beta antibody; SMC1beta protein antibody; Smc1l2 antibody; Structural maintenance of chromosomes 1-like 2 antibody; Structural maintenance of chromosomes 1B antibody; Structural maintenance of chromosomes protein 1B antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Structural maintenance of chromosomes protein 1B protein (954-1060AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I.
  • 基因功能參考文獻：
    1. Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility. PMID: 28364521
    2. Data show that structural maintenance of chromosomes protein 1B (SMC1B) is expressed in primary fibroblasts. PMID: 26673124
    3. High SMC1B expression is associated with pancreatic cancer. PMID: 25216700
  • 亞細胞定位：
    Nucleus. Chromosome. Chromosome, centromere.
  • 蛋白家族：
    SMC family, SMC1 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11112

    OMIM: 608685

    KEGG: hsa:27127

    STRING: 9606.ENSP00000350036

    UniGene: Hs.334176