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THNSL2 Antibody

  • 中文名稱：
    THNSL2兔多克隆抗體
  • 貨號：
    CSB-PA803155LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate
      All lanes: THNSL2 antibody at 4.3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 55, 46, 43, 48, 28 kDa
      Observed band size: 55 kDa
    • IHC image of CSB-PA803155LA01HU diluted at 1:400 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) THNSL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    THNSL2
  • 別名：
    THNSL2 antibody; Threonine synthase-like 2 antibody; TSH2 antibody; EC 4.2.3.- antibody; Secreted osteoclastogenic factor of activated T-cells antibody; SOFAT antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Threonine synthase-like 2 protein (295-441AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，THNSL2 Antibody (CSB-PA803155LA01HU)，的標(biāo)記方式是Non-conjugated。對于THNSL2 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA803155LB01HU THNSL2 Antibody, HRP conjugated ELISA
    FITC CSB-PA803155LC01HU THNSL2 Antibody, FITC conjugated
    Biotin CSB-PA803155LD01HU THNSL2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate.; Potent inducer of osteoblastic production of IL6. May act to exacerbate inflammation and/or bone turnover under inflammatory conditions.
  • 基因功能參考文獻(xiàn)：
    1. Our results provide evidence for new loci influencing abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2) previously reported to be associated with abdominal fat in women. PMID: 26480920
    2. These data support a putative role of SOFAT in the bone loss associated with chronic periodontal disease. PMID: 27035849
    3. may exacerbate inflammation and support osteoclast formation and bone destruction PMID: 25916677
    4. The present study demonstrated that SOFAT may play an important role in periodontitis. PMID: 23619471
    5. THNSL2 was found to have bimodal expression in human skeletal muscle tissue. PMID: 21299892
    6. A cytokine named SOFAT (secreted osteoclastogenic factor of activated T cells) can induce osteoblastic IL-6 production and osteoclast formation in the absence of osteoblasts or RANKL. It is insensitive to RANKL inhibitor osteoprotegerin. PMID: 19877052

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  • 亞細(xì)胞定位：
    [Isoform SOFAT]: Secreted. Note=Secreted by activated T-cells via a calcineurin-independent pathway.
  • 蛋白家族：
    Threonine synthase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25602

    OMIM: 611261

    KEGG: hsa:55258

    STRING: 9606.ENSP00000327323

    UniGene: Hs.739080