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  4. VGLL4 Antibody, HRP conjugated

VGLL4 Antibody, HRP conjugated

  • 中文名稱：
    VGLL4兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA613487LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) VGLL4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    VGLL4
  • 別名：
    VGLL4 antibody; KIAA0121 antibody; Transcription cofactor vestigial-like protein 4 antibody; Vgl-4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Transcription cofactor vestigial-like protein 4 protein (43-277AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May act as a specific coactivator for the mammalian TEFs.
  • 基因功能參考文獻(xiàn)：
    1. Hippo pathway transcription factor TEAD4 directly associates with the Wnt pathway transcription factor TCF4 via their DNA-binding domains, forming a complex on target genes. VGLL4 binds to this TEAD4-TCF4 complex to inhibit transactivation of both TCF4 and TEAD4. PMID: 28051067
    2. Results identify VGLL4 as a direct target gene of miR-130b in Bladder cancer (BCa) cells. Its suppression is crucial for miR-130b-induced BCa cell proliferation, migration and invasion. PMID: 29512748
    3. The Vgll4 is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) during antimitotic drug-induced mitotic arrest and also in normal mitosis. PMID: 28739871
    4. VGLL4 - novel candidate genes validated in a large case-control sample of schizophrenia. PMID: 26460480
    5. The expression level of VGLL4 protein was down-regulated in gastric cancer tissues.VGLL4 inhibits epithelial-mesenchymal transition in part through suppressing Wnt-beta-catenin signaling pathway in gastric cancer. PMID: 25701461
    6. our study suggested that downregulation of VGLL4 was very important in the progression of ESCC, and restoring the function of VGLL4 might be a promising therapeutic strategy for ESCC. PMID: 25352025
    7. VGLL4 directly competes with YAP in binding to TEADs and executes its growth-inhibitory function through two TDU domains. PMID: 24458094
    8. rs2616551 in VGLL4 was found to be nominally associated with anorexia nervosa. PMID: 24983835
    9. This study introduces a novel gain-of-function approach for studying hESC maintenance and presents VGLL4 as a previously undescribed regulator of this process. PMID: 23765749
    10. Loss of VGLL4 expression is associated with gastric cancer. PMID: 24525233
    11. Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments. PMID: 21839727
    12. IRF2BP2 was identifies as a novel VGLL4 partner. PMID: 20702774
    13. Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes PMID: 15140898
    14. A transcriptional cofactor of transcriptional enhancer factor-1 (TEF-1) transcription factors. Interacts with TEF-1 factors through 2 TDU (tondu) motifs. Controls gene expression in cardiac myocytes. PMID: 15140898
    15. This gene is named Vestigial-like 4, to distinguish it from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains 2 motifs, found in the Drosophila transcription cofactor Vestigial, that interact with the TEF-1 family of transcription factors. PMID: 15140898

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Vestigial family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28966

    KEGG: hsa:9686

    STRING: 9606.ENSP00000404251

    UniGene: Hs.740389