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  4. YEATS4 Antibody

YEATS4 Antibody

  • 中文名稱：
    YEATS4兔多克隆抗體
  • 貨號：
    CSB-PA026252ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: YEATS4 antibody at 1.44µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: Rat gonad tissue
      Lane 3: U251 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) YEATS4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    YEATS4
  • 別名：
    4930573H17Rik antibody; B230215M10Rik antibody; GAS 41 antibody; Gas41 antibody; glioma amplified sequence 41 antibody; Glioma-amplified sequence 41 antibody; glioma-amplified sequence-41 antibody; gliomaamplified sequence 41 antibody; gliomaamplified sequence41 antibody; NUBI 1 antibody; NuBI-1 antibody; NuBI1 antibody; NuMA binding protein 1 antibody; NuMA-binding protein 1 antibody; YAF9 antibody; YEATS domain containing 4 antibody; YEATS domain containing4 antibody; YEATS domain-containing protein 4 antibody; YEATS4 antibody; YETS4_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Rat
  • 免疫原：
    Recombinant Human YEATS domain-containing protein 4 protein (1-227AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Chromatin reader component of the NuA4 histone acetyltransferase (HAT) complex, a complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Specifically recognizes and binds acylated histone H3, with a preference for histone H3 diacetylated at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac) or histone H3 diacetylated at 'Lys-14' and 'Lys-27' (H3K14ac and H3K27ac). Also able to recognize and bind crotonylated histone H3. May also recognize and bind histone H3 succinylated at 'Lys-122' (H3K122succ); additional evidences are however required to confirm this result in vivo. Plays a key role in histone variant H2AZ1/H2A.Z deposition into specific chromatin regions: recognizes and binds H3K14ac and H3K27ac on the promoters of actively transcribed genes and recruits NuA4-related complex to deposit H2AZ1/H2A.Z. H2AZ1/H2A.Z deposition is required for maintenance of embryonic stem cell.
  • 基因功能參考文獻(xiàn)：
    1. Cellular and structural studies revealed that GAS41 is a histone lysine succinylation reader owing to a protonated histidine residue located inside the pocket. PMID: 29463709
    2. study identifies GAS41 as a histone acetylation reader that promotes histone H2A.Z deposition in non-small cell lung cancer. PMID: 29437725
    3. our study demonstrated the oncogenic roles of YEATS4 in the progression of pancreatic cancer by activating beta-catenin/TCF signaling and suggested that YEATS4 might be a promising therapeutic target for pancreatic cancer. PMID: 28445953
    4. Results showed that increased expression of YEATS4 might play a critical role in promoting GC cell proliferation and apoptosis by activating the Wnt/beta-catenin signaling pathway. PMID: 28251887
    5. identified GAS41 as a novel target for endogenous miR-203 and demonstrate an inverse correlation of miR-203 expression with GAS41 in glioma cell lines PMID: 27467502
    6. miR-218 sensitized HCT-116/L-OHP cells to L-OHP-induced cell apoptosis via inhibition of cytoprotective autophagy by targeting YEATS4 expression. PMID: 27779719
    7. YEATS4 overexpression is associated with drug resistance of ovarian cancer. PMID: 26307679
    8. Findings reveal YEATS4 as a candidate oncogene amplified in NSCLC, and a novel mechanism contributing to NSCLC pathogenesis PMID: 24170126
    9. Our data confirm previous genome-wide findings at 12q15 and suggest differential YEATS4 expression could underpin rs7297610-associated HCTZ response variability, which may have future implications for guiding thiazide treatment. PMID: 22350108
    10. GAS41 amplification results in overexpression and associtated with glioblastoma. PMID: 22619067
    11. Gas41 is able to bind both n-Myc and c-Myc proteins, and that the levels of expression of Gas41 and Myc proteins were similar to each other in such brain tumors as neuroblastomas and glioblastomas. PMID: 22068108
    12. The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability PMID: 21317290
    13. The in vivo interaction of GAS41 and endogenous RAP30 and RAP74 was confirmed by co-immunoprecipitation. GAS41 binds to two non-overlapping regions of the C-terminus of RAP30. PMID: 20618999
    14. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells PMID: 11903063
    15. GAS41 plays a role in repressing the p53 tumor suppressor pathway during the normal cell cycle by a TIP60-independent mechanism. PMID: 16705155
    16. Overexpression of YEATS4 is associated with well-differentiated and dedifferentiated liposarcomas PMID: 18214854

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24859

    OMIM: 602116

    KEGG: hsa:8089

    STRING: 9606.ENSP00000247843

    UniGene: Hs.4029