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CD14

CD14,全稱為單核細胞分化抗原CD14,也被稱作MY23、LeuM3或p55,是一種主要分布于單核細胞、巨噬細胞及中性粒細胞表面的糖蛋白。CD14作為脂多糖(LPS)的高親和力受體,能夠識別并結(jié)合細菌內(nèi)毒素,通過與TLR4受體形成復(fù)合物激活下游免疫應(yīng)答。在感染過程中,CD14通過TLR4/MyD88依賴的信號通路觸發(fā)NF-κB等轉(zhuǎn)錄因子活化,誘導TNF-α、IL-6等促炎因子釋放,參與膿毒癥、慢性炎癥性疾病的發(fā)展。臨床研究發(fā)現(xiàn),CD14基因多態(tài)性與動脈粥樣硬化、阿爾茨海默病及類風濕性關(guān)節(jié)炎等疾病風險相關(guān),其表達水平在膿毒癥患者血液中顯著升高,已成為感染性休克的潛在生物標志物。針對CD14的抗體藥物(如IC14)已進入臨床試驗階段,用于中和內(nèi)毒素引發(fā)的過度炎癥反應(yīng),同時基于TLR4-CD14信號軸的小分子抑制劑也在探索治療自身免疫性疾病的新策略。

熱銷產(chǎn)品

Recombinant Human Monocyte differentiation antigen CD14 (CD14), partial (Active) (CSB-MP004879HU1)

驗證數(shù)據(jù)

CSB-MP004879HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP004879HU1

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD14 at 2 μg/ml on an Nickel Coated plate can bind Anti-CD14 recombinant antibody (CSB-RA004879MA1HU). The EC50 is 2.148-2.447 ng/mL.

Recombinant Human Monocyte differentiation antigen CD14 (CD14) (CSB-EP004879HU)

驗證數(shù)據(jù)

CSB-EP004879HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CD14 Recombinant Monoclonal Antibody (CSB-RA004879MA1HU)

驗證數(shù)據(jù)

CSB-RA004879MA1HU

IHC image of CSB-RA004879MA1HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA004879MA1HU

The Binding Activity of Human CD14 with Anti-CD14 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD14 (CSB-MP004879HU1) at 2 μg/mL on an Nickel Coated plate can bind Anti-CD14 recombinant antibody. The EC50 is 2.148-2.447 ng/mL.

Human soluble cluster of differentiation 14,sCD14 ELISA Kit (CSB-E13199h)

驗證數(shù)據(jù)

CSB-E13199h 標準曲線

貨號:CSB-E13199h

規(guī)格:96T/48T

靈敏度:0.229 ng/mL

檢測范圍:0.234 ng/mL-15 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CD14 Antibodies

CD14 for Homo sapiens (Human)

CD14 Proteins

CD14 Proteins for Mus musculus (Mouse)

CD14 Proteins for Homo sapiens (Human)

CD14 Proteins for Oryctolagus cuniculus (Rabbit)

CD14 Proteins for Rattus norvegicus (Rat)

CD14 Proteins for Bos taurus (Bovine)

CD14 ELISA Kit

CD14 ELISA Kit for Homo sapiens (Human)

CD14 ELISA Kit for Rattus norvegicus (Rat)