CYBB全稱為細(xì)胞色素b-245重鏈（Cytochrome b-245 heavy chain），又稱NOX2或gp91phox，是NADPH氧化酶復(fù)合物的核心催化亞基。CYBB主要分布于中性粒細(xì)胞、單核細(xì)胞等吞噬細(xì)胞的細(xì)胞膜上，負(fù)責(zé)催化氧分子生成超氧陰離子，構(gòu)成機(jī)體抵抗病原微生物的關(guān)鍵防線。當(dāng)免疫細(xì)胞識(shí)別入侵病原體時(shí)，CYBB蛋白會(huì)與多個(gè)調(diào)控亞基組裝形成活性酶復(fù)合體，通過(guò)"呼吸爆發(fā)"產(chǎn)生大量活性氧直接殺傷細(xì)菌，這一過(guò)程被稱為氧化殺菌作用。CYBB基因突變會(huì)導(dǎo)致慢性肉芽腫?。–GD），患者因無(wú)法有效清除病原體而反復(fù)發(fā)生嚴(yán)重感染，并伴隨肉芽腫形成和炎癥過(guò)度反應(yīng)。針對(duì)該疾病的治療除了抗生素預(yù)防和干擾素-γ輔助治療外，干細(xì)胞基因治療已進(jìn)入臨床試驗(yàn)階段，通過(guò)回輸攜帶正常CYBB基因的造血干細(xì)胞實(shí)現(xiàn)功能修復(fù)?；贜OX2調(diào)控機(jī)制的抗氧化劑和抗炎藥物研究也為相關(guān)免疫缺陷及炎癥性疾病提供了新思路。

熱銷產(chǎn)品

Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial (CSB-EP006325HU1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CYBB Recombinant Monoclonal Antibody (CSB-RA006325MA1HU)

驗(yàn)證數(shù)據(jù)

Immunofluorescence staining of hela cell with CSB-RA006325MA1HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).